Lansoprazole reduced recurrence of ulcer complications in long-term use of low-dose aspirin.

نویسنده

  • Colin W Howden
چکیده

Patients 123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for > 1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection that was objectively diagnosed. Exclusion criteria included oesophagitis; a history of gastric or duodenal surgery other than oversewing of a perforation; allergy to study drugs; H pylori infection that could not be eradicated after 2 attempts with eradication therapies; and concomitant treatment with nonsteroidal anti-inflammatory drugs, corticosteroids, or anticoagulants. Follow up was 92%.

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Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.

BACKGROUND The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain. METHODS We enrolled 123 patients who had ulcer complications after using low-dose aspirin continuously for more than one month and who had H. pylori infection. After the ulcers had...

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عنوان ژورنال:
  • ACP journal club

دوره 138 1  شماره 

صفحات  -

تاریخ انتشار 2003